Basal-Like Atypical Ductal Hyperplasia and Basal-Like Ductal Carcinoma In Situ: Evidence for Precursor of Basal-Like Breast Cancer
نویسندگان
چکیده
Basal-like breast cancer (BLBC) is identified by gene expression profiling studies and associated with worse overall survival. The identification of possible precursors BLBC important to gain insight into tumorigenesis therapeutic targets.
منابع مشابه
Identification of a basal-like subtype of breast ductal carcinoma in situ.
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Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific bio...
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Introduction Cytokeratin (CK) 14, one of several markers expressed in normal myoepithelial/basal cells, is also expressed in a proportion of breast carcinomas. Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas. Methods We performed CK14 immunohis...
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Recent gene expression profiling of breast cancer has identified specific subtypes with clinical, biologic, and therapeutic implications. The basal-like group of tumors is characterized by an expression signature similar to that of the basal/myoepithelial cells of the breast and is reported to have transcriptomic characteristics similar to those of tumors arising in BRCA1 germline mutation carr...
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ژورنال
عنوان ژورنال: International journal of pathology and clinical research
سال: 2022
ISSN: ['2469-5807']
DOI: https://doi.org/10.23937/2469-5807/1510132